CompletedPhase 1

ACTolog in Patients With Solid Cancers

United States38 participantsStarted 2017-06-30

Plain-language summary

The study purpose is to learn about the safety and tolerability of IMA101 alone (Cohort 1) or in combination with atezolizumab (Cohort 2) in patients with advanced solid cancers that express pre-defined Immatics tumor targets.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Patients must have pathologically confirmed advanced/metastatic cancer prior to enrollment.
. HLA phenotype positive.
. Eastern Cooperative Oncology Group (ECOG) performance status 0-1.
. Life expectancy \> 6 months prior to enrollment.
. Patient is a candidate for a maximum of one further line of established therapy (prior to treatment with ACTolog).
. The patient has adequate organ and marrow function per protocol
. At least one lesion (metastasis or primary tumor) being considered accessible by non-high-risk collection procedures for biopsy.
. The patient has adequate hepatic function per protocol

Exclusion criteria

. Any condition contraindicating leukapheresis.
. Patients with brain metastases. Patients with a history of brain metastases may be eligible, if an imaging scan with contrast enhancement not older than 4 weeks is able to exclude the existence of currently active brain metastasis.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Incidence of adverse events (Safety and tolerability) of IMA101 alone or in combination with atezolizumab

Timeframe: up to 18 months

Trial details

NCT IDNCT02876510

SponsorImmatics US, Inc.

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2021-09-22

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