CompletedNot Applicable

The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents

1,200 participantsStarted 2016-09-01

Plain-language summary

This study to collect and identify rodents and mites across transects through diverse habitats used by the human community from a localised area identified as a scrub typhus 'hot spot'.

Who can participate

Age range

10 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Presenting with fever \>38 C and testing positive by scrub typhus RDT.
. Male or Female, aged 10 years or above.
. Participant is willing and able to give informed consent for participation in the study.
. Villagers living in an environment in which scrub typhus is known to be present, who are asymptomatic.
. Male or Female, aged 10 years or above.
. Participant is willing and able to give informed consent for participation in the study.

Exclusion criteria

. Villagers/patients under 10 years of age.
. Those unwilling to give written informed consent.
. Villagers/patients under 10 years of age.
. Those unwilling to give written informed consent.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

determine the diversity of O. tsutsugamushi genotypes infecting rodents and mites and link these to their geographical distribution and associated habitat characteristics.

Timeframe: up to 24 months

Correlate the frequency of O. tsutsugamushi in mites and rodents with habitat characteristics, to define interactions between distribution and transmission dynamics.

Timeframe: up to 24 months

Identify key mite vectors and rodent hosts involved in scrub typhus natural history, human infection, and disease virulence

Timeframe: up to 24 months

Trial details

NCT IDNCT02876367

SponsorUniversity of Oxford

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-04-10

View on ClinicalTrials.gov More Scrub Typhus trials

Who can participate

Age range

10 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Presenting with fever \>38 C and testing positive by scrub typhus RDT.
. Male or Female, aged 10 years or above.
. Participant is willing and able to give informed consent for participation in the study.
. Villagers living in an environment in which scrub typhus is known to be present, who are asymptomatic.
. Male or Female, aged 10 years or above.
. Participant is willing and able to give informed consent for participation in the study.

Exclusion criteria

. Villagers/patients under 10 years of age.
. Those unwilling to give written informed consent.
. Villagers/patients under 10 years of age.
. Those unwilling to give written informed consent.

What they're measuring

determine the diversity of O. tsutsugamushi genotypes infecting rodents and mites and link these to their geographical distribution and associated habitat characteristics.

Timeframe: up to 24 months

Correlate the frequency of O. tsutsugamushi in mites and rodents with habitat characteristics, to define interactions between distribution and transmission dynamics.

Timeframe: up to 24 months

Identify key mite vectors and rodent hosts involved in scrub typhus natural history, human infection, and disease virulence

Timeframe: up to 24 months