CompletedNot Applicable

The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents

1,200 participantsStarted 2016-09-01

Plain-language summary

This study to collect and identify rodents and mites across transects through diverse habitats used by the human community from a localised area identified as a scrub typhus 'hot spot'.

Who can participate

Age range10 Years

SexALL

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Inclusion criteria

✓. Presenting with fever \>38 C and testing positive by scrub typhus RDT.
✓. Male or Female, aged 10 years or above.
✓. Participant is willing and able to give informed consent for participation in the study.
✓. Villagers living in an environment in which scrub typhus is known to be present, who are asymptomatic.
✓. Male or Female, aged 10 years or above.
✓. Participant is willing and able to give informed consent for participation in the study.

Exclusion criteria

✕. Villagers/patients under 10 years of age.
✕. Those unwilling to give written informed consent.
✕. Villagers/patients under 10 years of age.
✕. Those unwilling to give written informed consent.

What they're measuring

determine the diversity of O. tsutsugamushi genotypes infecting rodents and mites and link these to their geographical distribution and associated habitat characteristics.

Timeframe: up to 24 months

Correlate the frequency of O. tsutsugamushi in mites and rodents with habitat characteristics, to define interactions between distribution and transmission dynamics.

Timeframe: up to 24 months

Identify key mite vectors and rodent hosts involved in scrub typhus natural history, human infection, and disease virulence

Timeframe: up to 24 months

Trial details

NCT IDNCT02876367

SponsorUniversity of Oxford

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-04-10

View on ClinicalTrials.gov More Scrub Typhus trials