CompletedPhase 4

Comparing Cefepime Versus Cefazolin Plus Ceftazidime for CAPD-associated Peritonitis

Thailand154 participantsStarted 2015-08

Plain-language summary

The purpose of this study is to compare the efficacy of empirical antibiotics of CAPD-associated peritonitis with intraperitoneal, continuous dosing of cefepime monotherapy versus combination of cefazolin and ceftazidime. Patients were randomized to be administered either intraperitoneal cefepime 1 g loading then 250 mg all exchanges (treatment group) or cefazolin and ceftazidime (control group) in the same dose.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age more than 18 years * CAPD initiation more than 4 weeks Exclusion Criteria: * Exit site or tunnel infection * Sepsis * Previous CAPD-associated peritonitis treatment within 4 weeks * Drug allergy to cephalosporin * Tenckhoff catheter malfunction * Hospitalization more than 48 hours * Fungal or Mycobacterium infection * Suspected secondary peritonitis * Concomitant antibiotics.

What they're measuring

Primary response rate

Timeframe: day 10 of treatment

Trial details

NCT IDNCT02872038

SponsorChulalongkorn University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-11-30

View on ClinicalTrials.gov More Peritoneal Dialysis Associated Peritonitis trials