CompletedNot Applicable

Correlation Between PET and Advanced MRI in Multiple Sclerosis

Canada14 participantsStarted 2016-10

Plain-language summary

Traditional Magnetic Resonance Imaging (MRI) in Multiple Sclerosis (MS) has enabled clinicians to measure disease activity but there are inherent limitations. Clinical/radiographic dissociation can be seen in some patients and the abnormalities are not specific. This pilot study is an opportunity to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health.

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosed with Multiple Sclerosis according to the 2011 McDonald criteria. * Aged 18 to 60 * High or mixed affinity binder to rs6971 TSPO polymorphism Exclusion Criteria: * Pregnant or breastfeeding * Suffering from an unstable medical condition * Have a neurological or ocular disorder other than MS * Any contra-indications to MRI

What they're measuring

Whole Brain PBR28 binding

Timeframe: Baseline

Trial details

NCT IDNCT02869360

SponsorUniversity of British Columbia

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-10-02

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