CompletedNot Applicable

Molecular and Clinical Profile of Von Willebrand Disease in Spain

Spain790 participantsStarted 2017-10-03

Plain-language summary

The present Project is a third phase of the previous PCM-EVW-ES Project (Batlle et al. Thromb \& Haemost 2015) with the aim of its extension, further analysis with an innovation development in the field of von Willebrand disease (VWD) based in the newer recently available methodologies. The aim of this project is to help the physician in a more uniform characterization and therapy of VWD in clinical practice, at an international level. A reduction of the expenses in the diagnosis process by using the new methodologies is pursued.

Who can participate

Age range

2 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. VWF ≤ 30 IU/d, in 2 or more occasions.
. Presence of multimeric abnormalities.
. If isolated FVIII deficiency demonstration of decreased FVIII binding.
. Presence of some VWF mutation.
. ↑ RIPA at low concentrations of ristocetin.

Exclusion criteria

. Presence of any data suggesting AVWS.
. Absence of a signed patient informed consent

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Central diagnosis of 400 new VWD Spanish patients

Timeframe: January 2019

Trial details

NCT IDNCT02869074

SponsorSpanish Society of Thrombosis and Haemostasis

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-09-25

View on ClinicalTrials.gov More Von Willebrand Disease trials