Binge Eating Disorder and Obesity : Functional MRI Study (NCT02868619) | Clinical Trial Compass
CompletedNot Applicable
Binge Eating Disorder and Obesity : Functional MRI Study
France32 participantsStarted 2014-12-05
Plain-language summary
Obesity, defined as BMI\> 30kg / m2, is a major public health problem, with devastating medical and psychological consequences. 30% of obese suffer from BED type of eating disorders. The optimal treatment of obesity remains bariatric surgery, failed in 20% of cases. Many arguments are in favor of the involvement of the reward circuitry, with the central role of NAc in the pathophysiology of BED and obesity. The recent application and effectiveness of DBS (Deep Brain Stimulation) in refractory psychiatric disorders suggest that DBS may be of interest in treating obesity and BED with potential target for the NAc. This project propose to study fMRI activation of the reward system in response to food stimuli to better direct the DBS targets. This is a pilot study to define indication criteria based on fMRI to obese BED patients are potential candidates for treatment with DBS.
Who can participate
Age range12 Years – 16 Years
SexALL
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Inclusion Criteria:
* Non specific inclusion criteria
* Age limits ≥ 12 et \< 16 years
* Collection of the informed consent. For the minor patients, signature of parents
* Affiliation or recipient with the mode of social security.
* No associated evolutionary pathologies
* Specific inclusion criteria for the patients
* Existence of a current food disorder of the conducts of type binge eating disorder according to the criteria Marcus and Kalarchian
* Diagnosis of obesity defined by a body mass index \> 97th percentile
* Severity criteria defined by: Evolution of the obesity and the BED for at least 5 years AND Not answer to a dietary, pharmacological, psychotherapeutic care during at least 6 months
* Specific inclusion criteria for the volunteers
* Absence of a current food disorder of the conducts of type binge eating disorder according to the criteria Marcus and Kalarchian
* Absence of antecedent of neurological disorder
* an actual body mass index \< 90th percentile
Exclusion Criteria:
* IRM contraindication
* Pacemaker
* Port(Bearing) of surgical clips in the cervico-cephalic region or implanted medical surgical material(equipment) susceptible to mobilize under the influence of magnetic gradients
* Intraocular foreign body
* Metalic foreign body
* claustrophobia
* The existence of possible psychiatric histories will be individually estimated
* Pregnancy and breastfeeding
* Loss of liberty by court or administrative order
What they're measuring
1
Differences in neural activation assessed during functional MRI