Slowing Down Disease Progression in Premanifest SCA: a Piloting Interventional Exergame Trial

Inclusion Criteria: * adult persons (age 18-80 years) who (i) are a blood-related relative of an index subject with a known SCA 1,2,3 or 6 mutation and who (ii) have a score value of \<8 points on the Scale for the Assessment and Rating of Ataxia (SARA) * full capacity to consent to study participation after extensive information (fully Informed Consent) Exclusion Criteria: * Cognitive deficits which prevent full comprehension of the study requirements and/or training requirements * Comorbid diseases that place severe constraints on a continous training with whole-body controlled exergames (e.g. severe visual or hearing deficits; severe paresis; severe movement disorders other than ataxia) * Comorbid neurologic disease other than ataxia (e.g. prior stroke or brain trauma) * Pregnant or breast-feeding persons * Lack of capacity for full informed consent according to established psychiatric criteria for full informed consent Magnetic Resonance Imaging (MRI) exclusion criteria: * cardiac pacemakers * artificial heart valves * metal prostheses * implanted magnetic metal parts (screws, plates and similar devices) * intrauterine devices (for instance, for contraceptive purposes) * shrapnel parts and other metal pieces * non-removable braces and metal dentures * non-removable acupuncture needles * insulin pumps and infusion ports * tattoos, eye shadow and other metal-containing make-up * The subject has decreased sensitivity to temperature and / or decreased tolerance towards e…