CompletedPhase 4

Dehydroepiandrosterone (DHEA)Supplementation Pre-IVF(In Vitro Fertilization) Cycles

78 participantsStarted 2014-12

Plain-language summary

The purpose of this study is to compare the effect of pre-IVF cycles treatment with and without DHEA(Dehydroepiandrosterone) on the ovarian reserve markers, the number of oocytes obtained and IVF(in vitro fertilization) outcomes of DOR(diminished ovarian reserve) patients and the expression of BMP-15(bone morphogenetic protein 15),GDF-9（growth differentiation factor 9) and IGF-I(insulin-like growth factors-1) in follicular fluid.

Who can participate

Age range25 Years – 42 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with antral follicle count \<5 or AMH\<1.1ng/ml and a previous poor ovarian reserve (POR)(\</= 3 oocytes with a conventional stimulation protocol using at least 150 IU FSH per day,at least two episodes) Exclusion Criteria: * Patients with polycystic ovary or polycystic ovary syndrome, patients who had previous chemotherapy, pelvic irradiation or ovarian surgery and patients on hormonal supplementation for any indication at the time of recruitment (e.g. estrogen, testosterone or DHEA).

What they're measuring

Implantation rate

Timeframe: 6 months

Trial details

NCT IDNCT02866253

SponsorShangHai Ji Ai Genetics & IVF Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-12

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