ADRENAL FUNCTION IN PATIENTS WITH ACUTE HEPATITIS

Inclusion Criteria: * Inclusion of 101 test subjects and for statistical analysis: * 29 patients with non-acute severe hepatitis (TP\> 50% and AST or ALT\> 500 IU / L or\> 10 xN for less than 15 days). * 43 patients with severe acute hepatitis (TP \<50%). Patients with suspected IS with the assay of the CTS will retested at Synacthène 4 to 6 months later (10 desired subjects). * 29 healthy volunteers (control group included in the analysis). * Inclusion of 10 patients with established IS (control group to estimate the low values of cortisol). * Patient who signed the consent of study participation Exclusion Criteria: * Women during pregnancy or breastfeeding * Minor and over 75 years * Major protected within the meaning of Huriet * Subject healthy volunteers in a sport competition * Patients transplanted, HIV infection (also refusing HIV status) or patients on immunosuppressive therapies (including corticosteroids) * ketoconazole Shot, rifampicin, mifepristone, megestrol or etomidate * Treatment with corticosteroids irrespective of the route of administration * severe acute alcoholic hepatitis * oral fungal infection * upper gastrointestinal bleeding or oral bleeding (contamination salivettes) * unbalanced Diabetes * unbalanced Hypertension * Chronic heart failure (stage III or IV of the classification of the New York Heart Association \[NYHA\]) * Inability to receive clear information in patients with severe encephalopathy and do not have someone you trust * Refusa…