CompletedNot Applicable

SI + CC Versus 3:1 C:V Ratio During Neonatal CPR

Austria, Canada27 participantsStarted 2017-10-19

Plain-language summary

Research question In newborn infants requiring CPR, does CC superimposed by sustained inflation compared to 3:1 compression to ventilation ratio improves return of spontaneous circulation? Overall objective: CC superimposed by sustained inflation will improve short- and long-term outcomes in preterm (\>28 weeks or older) and term newborns. Hypothesis to be tested Primary hypothesis: By using CC superimposed by sustained inflation (CC+SI) during CPR the time needed to achieve return of spontaneous circulation (ROSC) compared to the current 3:1 compression to ventilation (C:V) will be reduced in asphyxiated newborns.

Who can participate

Age range0 Minutes – 20 Minutes

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Infants (term or preterm infants \>28 weeks' gestation) requiring CC in the delivery room will be eligible for the trial. Exclusion Criteria: * Infants will be excluded if they have a congenital abnormality or condition that might have an adverse effect on breathing or ventilation (e.g. congenital diaphragmatic hernia), or congenital heart disease requiring intervention in the neonatal period. Infants would be also excluded if their parents refused to give consent to this study.

What they're measuring

Return of Spontaneous Circulation

Timeframe: up to 60 Minutes of chest compression

Trial details

NCT IDNCT02858583

SponsorUniversity of Alberta

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-09-22

Results submitted2023-07-17

View on ClinicalTrials.gov More Heart Arrest trials