TerminatedNot Applicable

Structural and Functional Brain Reorganization in Neuropathic Pain. Influences of the Loss of Sensitivity and the Atrophy Cortical on Activations Due to Stimulation Allodynic

Stopped: failure to recruit

France41 participantsStarted 2016-03-25

Plain-language summary

Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation). This pain is secondary to nervous system injury affecting the sensory system. The lesion is either at the nerve endings of the spinal cord or brain. It induces a loss of sensitivity and reorganization of brain activity. Previous studies in functional neuroimaging have focused on brain areas activated during allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but it was not possible to conclude formally. The objective of this study is to understand the brain dysfunction that induces allodynic pain considering the deafferentation of each patient and possible cortical losses.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * with neuropathic pain * in the case of central lesions, the lesion must be unique and small * treatment not stable opioid for one week * consent signed Exclusion Criteria: * severe psychiatric history * presence of an evolutive lesion, expansive, cancerous or tumorous underlying * patient needing of opioid therapy * contraindication at MRI scan

What they're measuring

the deafferentation rate

Timeframe: at baseline

gray matter rate

Timeframe: at baseline

Trial details

NCT IDNCT02858479

SponsorCentre Hospitalier Universitaire de Saint Etienne

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-02-11

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