CompletedNot Applicable

Unlock the Cell: Castleman's Disease Flow Cytometry Study

United States130 participantsStarted 2016-02

Plain-language summary

Castleman disease, a rare lymphoproliferative disorder, is characterized by inflammatory cytokine production and multiple organ system dysfunction. In this study, we will investigate inflammatory markers, cells, and signaling pathways in prospectively collected blood samples and/or buccal swabs or saliva using biochemical and RT-PCR techniques, proteomics, genomics, immunohistochemistry, storage for future use, cell culture treated with external stimuli, flow cytometry, and other molecular tests

Who can participate

SexALL

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Inclusion Criteria: * CD patients: Individuals of any age who are diagnosed with or suspected by a physician to have CD, including those who do have the ability to consent and those who lack the ability to consent * Related Disease: Individuals who state that they have a disease that is a "Related Disease". "Related Disease" means autoimmune, oncology, inflammatory/lymphoproliferative disorders and infectious diseases that are similar to Castleman * Healthy Individuals: Individuals without a history of auto-immune, inflammatory, infectious disease or oncologic disorders. Exclusion Criteria: • All individuals whose medical or psychological conditions (such as a mental handicap) would, in the opinion of the Principal Investigator, compromise the subject's safety or successful participation in the study.

What they're measuring

Collect PBMCs to use for inflammatory cell profiling via FACS

Timeframe: 1 year ~

Collect PBMCs to use for cell culture experiments

Timeframe: 1 year ~

Trial details

NCT IDNCT02853968

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-01-30

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