Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery Du… (NCT02853682) | Clinical Trial Compass
CompletedNot Applicable
Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery
France28 participantsStarted 2016-01-20
Plain-language summary
The glycocalyx is a layer of proteins and complex sugars covering the endothelium of vessels. Its role as capillary filtration control is important. In case of alteration of the glycocalyx, experimental models and some clinical studies show an increased capillary leak responsible for interstitial edema. The analysis of glycocalyx in routine care is important to guide volume expansion. Indeed, the literature provides evidence about the poor prognosis of excess water and its impact on organ. This analysis challenge is to justify filling solution of choice according to the characteristic of this capillary leakage.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial studied something called glycocalyx proteins in relation to capillary leak syndrome during cardiac surgery — can you explain what the glycocalyx is and why measuring it during surgery might matter for my care?
2Since this trial is already completed, has the data been published yet, and if so, what did it find about how the brachial artery blood flow measurements reflected endothelial dysfunction in cardiac surgery patients?
3The trial focused on characterizing endothelial dysfunction rather than testing a new treatment — does that mean the goal was purely to better understand what happens to blood vessels during cardiac surgery, and how might those findings influence how my surgical team monitors or manages me?
4Capillary leak syndrome can be a serious complication of cardiac surgery — based on what this study found, are there any warning signs or measurements my care team would now watch for more closely during or after my procedure?
5Since this was a characterization study rather than a drug or device trial, should I be looking at other trials that are now using these findings to actually test a prevention or treatment strategy for capillary leak syndrome?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.