CompletedNot Applicable

GTA-MEG as a Biomarker for Cognition in MS

Belgium159 participantsStarted 2016-04

Plain-language summary

In this study, 100 persons with Multiple Sclerosis and 50 matched controls will be examined with magnetoencephalography (MEG), magnetic resonance imaging (MRI) and cognitive tests. The primary hypothesis for the study is: Interhemispheric connectivity, determined using graph theoretic analysis (GTA) on source-reconstructed MEG data, is a biomarker for cognitive deterioration in MS, which has value at the individual patient level.

Who can participate

Age range18 Years – 55 Years

SexALL

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Inclusion Criteria: * Multiple sclerosis according to the modified McDonald criteria * Expanded Disability Status Scale (EDSS) below 6.0 * Providing informed consent * Age between 18 and 55 years Exclusion Criteria: • Major medical or psychiatric pathology that potentially influences cognition

What they're measuring

MEG Contrasts of parameter estimates (COPE)

Timeframe: 0 to 1000 msec post stimulus

Trial details

NCT IDNCT02851342

SponsorUniversitair Ziekenhuis Brussel

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-01

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