The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery

Inclusion Criteria: * patients age 65 and over * fracture of the proximal femur * preoperative assessment American Society of Anesthesiologists(ASA) score I - ASA III * a written consent of the patient to participate in research Exclusion Criteria: * patient non-compliance * ASA status IV and IV above * patients younger than 65 years * dementia, Parkinson's disease, cerebrovascular accident history; simultaneous head injuries,the use of opioids and benzodiazepines longer than a month before the surgery; alcoholism; serious liver disease (class C according to Child-Pugh's classification); severe kidney disease that require dialysis * result of MMSE test (Mini-Mental State Examination) under 17 * the existence of any contraindications for the implementation of regional anesthesia and one or other form of post-operative analgesia.