Stereotactic Laser Ablation for Temporal Lobe Epilepsy (Slate)

Inclusion Criteria: * History of drug-resistant mesial temporal lobe epilepsy (MTLE) * If the subject has a vagus nerve stimulator (VNS), must have failed to achieve sustained seizure freedom with the VNS implanted for at least 6 months * On stable antiepileptic drugs (AEDs) (and/or stable VNS setting, if applicable) and compliant with medication use * An average of at least 1 complex partial or secondarily generalized seizure compatible with MTLE per month * Seizure symptoms and/or auras compatible with MTLE * Video EEG shows evidence of seizures from one temporal lobe consistent with MTLE * MRI has evidence consistent with mesial temporal lobe sclerosis * Willing and able to remain on stable AEDs (and stable VNS setting, if applicable) for 12 months following the Visualase procedure * Willing and able to comply with protocol requirements * Able to complete study assessments in English or Spanish language Exclusion Criteria: * Unwilling or unable to sign the study informed consent form * Pregnant or intends to become pregnant during the course of the study * Currently implanted with a device contraindicating MRI * Progressive brain lesions and/or tumors not associated with epileptic disease state * History of previous intracranial surgery for treatment of epileptic seizures * Persistent extra-temporal or predominant contralateral focal interictal spikes or slowing, or generalized interictal spikes on EEG * Seizures with contralateral or extra-temporal ictal onset on EEG *…