Comparison of ASCT and Conventional Chemotherapy in High Risk Waldenström Macroglobulinemia (NCT02844361) | Clinical Trial Compass
CompletedPhase 4
Comparison of ASCT and Conventional Chemotherapy in High Risk Waldenström Macroglobulinemia
China70 participantsStarted 2016-05
Plain-language summary
The purpose of this study is to evaluate whether autologous stem cell transplantation will improve the survival of patients with high-risk Waldenström macroglobulinemia, compared with conventional chemotherapy.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. 70 years\>=Aged \>=18 years
. diagnosed with high-risk LPL/WM according to the ISSWM criteria
. untreated or mild treated without standard regimens
. suitable for ASCT
. with life-expectancy more than 3 months.
Exclusion criteria
. diagnosed with other malignancies outside B-NHL within one year(including active center neural system lymphoma)
. transformed lymphoma
. liver or renal function lesion unrelated to lymphoma
. serious complications such as uncontrolled diabetes, gastric ulcer or other serious angiocardiopathy determined by the physician
. HIV positive or active HBV infection or other uncontrolled systematic infection
. clinical central nervous dysfunction
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
progress-free survival
Timeframe: up to 36 months
Trial details
NCT IDNCT02844361
SponsorInstitute of Hematology & Blood Diseases Hospital, China