CompletedNot Applicable

The Use of Self-reported Symptoms as a Proxy for Acute Organophosphate Poisoning Among Nepali Farmers

42 participantsStarted 2014-09

Plain-language summary

The purpose of this study is to evaluate self-reported symptoms as a proxy for acute organophosphate poisoning by examining self-reported acute organophosphate poisoning symptoms and PchE activity in response to occupational acute organophosphate exposure among farmers in Nepal.

Who can participate

Age range18 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * male * minimum age 18 years * hand pressured backpack sprayer usage * used to spray with moderately to extremely hazardous pesticides according to the World Health Organization's (WHO) Pesticide Hazard Classification Exclusion Criteria: * usual personal protective equipment use (respirator/mask with particulate filter, face shield, googles, gloves, boots, plastic poncho) * unwilling to stay pesticide-free seven days prior to each of the two spray sessions * medical conditions interfering with PchE activity (liver disease, acute infection, chronic malnutrition, heart attack, cancer, obstructive jaundice, inflammation caused by various diseases, or use of pyridostigmine drugs)

What they're measuring

Change in self-reported acute organophosphate poisoning symptoms from baseline to follow up

Timeframe: Obtained just before (baseline) and 30 minutes after (baseline) each spray session

Change in Plasma Cholinesterase (PchE) activity from baseline to follow up

Timeframe: Obtained just before (baseline) and 30 minutes after (baseline) each spray session

Trial details

NCT IDNCT02838303

SponsorBispebjerg Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-11

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