TerminatedNot Applicable

Effects of Botulinum Toxin on Muscle and Brain Activity

Stopped: Inability to recruit controls and limited research staff to complete project.

United States18 participantsStarted 2016-08

Plain-language summary

This study will look into the effects of Botulinum Toxin in patients with primary cervical dystonia. The effects will be determined by neck muscle activity measurements and brain function activity measurements. The goal of the study is to try to identify markers of the effects of Botulinum toxin.

Who can participate

Age range21 Years – 85 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Subject inclusion criteria: * Diagnosis: PCD * Receiving BoNT at the University of Florida (UF) Subject exclusion criteria: * Secondary torticollis * Pregnancy * Active seizure disorder * Presence of metallic body such as pacemaker, implants, metal rods and hearing aid Control inclusion criteria: * Age 21-80 years Control exclusion criteria: * Any form of torticollis * Pregnancy * Active seizure disorder * Presence of metallic body such as pacemaker, implants, metal rods and hearing aid

What they're measuring

Changes in TMS measures

Timeframe: Baseline, BoNT ON (around 6 weeks), BoNT OFF (around 12 weeks) for Arm 1; Arm 2 measured only at baseline

Changes in EMG measures

Timeframe: baseline, BoNT ON (around 6 weeks), BoNT OFF (around 12 weeks) for Arm 1; Arm 2 measured only at baseline

Trial details

NCT IDNCT02837185

SponsorUniversity of Florida

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-09-26

View on ClinicalTrials.gov More Cervical Dystonia, Primary trials