Natural Cycle Versus Stimulated Cycle Before Frozen Embryo Transfer (NCT02834117) | Clinical Trial Compass
CompletedPhase 4
Natural Cycle Versus Stimulated Cycle Before Frozen Embryo Transfer
France124 participantsStarted 2015-05
Plain-language summary
Embryo freezing is a technique used regularly to optimize the pregnancy rate in case of infertility. This method is performed in presence of supernumerary embryo(s) after fresh transfer, or after freeze all embryos in case of medical reasons. It is necessary to control that the transfer is performed when the endometrium is receptive, which is essential for embryo implantation and pregnancy. This period is defined as the "implantation window". Endometrial preparation can be achieved by hormone replacement therapy (HRT) or moderate ovarian stimulation (SO). The implantation window can also be assessed by monitoring of a natural cycle (NC). The objectives of this open randomized study is to compare the number of visits (ultrasound and blood tests) induced by the SO or NC as well as the women quality of life in both groups.
Who can participate
Age range
20 Years – 38 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Affiliation to the general social security regime and benefiting from 100% infertility;
* Regular Cycles 26 to 35 days;
* Support in IVF or ICSI ;
* Existence of at least 2 frozen embryos to J2 or J3;
* Treated for their first or second cycle of TEC.
Exclusion Criteria:
* Donor sperm;
* Irregular cycles and / or polycystic ovary syndrome;
* Embryos frozen at J1 or J5 / J6 or double planned transfer or transfer of 3 embryos intended;
* Patients who have had more than 3 transfers or more than 6 embryos replaced without pregnancy or puncture rank\> 3;
* uterine malformation existing;
* Presence of a hydrosalpinx.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Number of visits
Timeframe: From inclusion visit to embryo transfer : up to 90 days