CompletedNot Applicable

Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients

France20 participantsStarted 2015-03

Plain-language summary

The objective is to investigate ex vivo the inflammatory response in hidradenitis suppurativa (HS) (activation of an inflammasome, role of pro-inflammatory cytokines) in the skin of patients treated surgically for this disease. The investigators hypothesize that Th17-derived cytokines, especially Interleukin (IL) IL-17, could serve as a relay in the inflammatory process leading to HS severity and recurrences.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with moderate to severe HS in the Dermatology department of Reims CHU, and eligible for surgery * Patients accepting to participate to the study (signed consent) * Patients affiliated to a certain social scheme * Controls with plastic surgery but without HS, affiliated to a certain social scheme and accepting to participate Exclusion Criteria: * Patients \<18yo

What they're measuring

cytokine quantification (IL1-β) by ELISA

Timeframe: up to 4 days

cytokine quantification (IL-10) by ELISA

Timeframe: up to 4 days

cytokines quantification (IL-13) by ELISA

Timeframe: up to 4 days

cytokines quantification (IL-18) by ELISA

Timeframe: up to 4 days

cytokines quantification (CXCL10) by ELISA

Timeframe: up to 4 days

cytokines quantification (TNFα) by ELISA

Timeframe: up to 4 days

cytokines quantification (TGFβ) by ELISA

Timeframe: up to 4 days

Trial details

NCT IDNCT02833909

SponsorCHU de Reims

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-03

View on ClinicalTrials.gov More Hidradenitis Suppurativa trials