TerminatedPhase 2

Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair

Stopped: Low recruitment and competing studies have published.

United States27 participantsStarted 2016-11

Plain-language summary

Patients with intrauterine adhesions (Asherman's Syndrome) and persistent thin endometrial lining in in vitro fertilization (IVF) treatment programs, particularly those resistant to standard therapies, present a significant clinical challenge. The aim of this trial is to assess if intrauterine administration of platelet rich plasma (PRP) improves endometrial lining thickness in patients with thin lining or Asherman's Syndrome.

Who can participate

Age range18 Years – 43 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Persistent thin lining \< 6mm on \>1 cycle in previous IVF or FET cycle OR moderate-to-severe Asherman's syndrome Exclusion Criteria: * Age \<18 years old or \>43 years old, * Pregnancy, * Diagnosis of cancer, * Hb \<11 g/dL, platelets \<150,000/mm3, * Anticoagulation, * NSAIDs in the 10 days before procedure * Any significant comorbidity or psychiatric disorder that would compromise patient safety or compliance, interfere with consent, study participation, follow up, or interpretation of study results. * Incision in the uterus: myomectomy; cesarean section

What they're measuring

Endometrial Thickness

Timeframe: 3-30 days after treatment

Trial details

NCT IDNCT02825849

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-08

Results submitted2020-12-02

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