CompletedNot Applicable

Identification of Carotid Plague Vulnerability by Contrast Enhanced Ultrasound: Correlation With Plague Histopathology

China50 participantsStarted 2016-01-13

Plain-language summary

OBJECTIVE/BACKGROUND: Intraplaque neovascularization is one of the most important risk factors for unstable carotid plaque. This study was designed to evaluate whether carotid intraplaque neovascularization (IPN) can be accurately assessed by contrast enhanced ultrasound (CEUS). METHODS: Preoperative CEUS analysis of 50 carotid artery stenosis patients would be compared to histopathology performed on their plaques excised by carotid endarterectomy (CEA) with CD34 and MMP9 staining.

Who can participate

Age range50 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * The patients with ischemic symptom whose carotid stenosis were more than 50% * The patients without ischemic symptom whose carotid stenosis were more than 70% Exclusion Criteria: * Confirmed with severe intracranial vascular lesions * Suffering from the large area cerebral infarction or critical stroke sequela * Restenosis after CEA or CAS * Suffering from severe coronary heart disease, respiratory failure,the hypertension difficult to controled * Patients with malignant tumor or expected life \< 2 years

What they're measuring

the incidence of ischemia shock

Timeframe: within 30 days after operations

Trial details

NCT IDNCT02820207

SponsorBeijing Tsinghua Chang Gung Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-11-30

View on ClinicalTrials.gov More Carotid Artery Plaque trials