Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye Disease

Inclusion Criteria: * Have a documented clinical diagnosis of dry eye disease in both eyes Exclusion Criteria: * Known hypersensitivity or contraindication to the investigational product(s) or components * History of glaucoma, IOP\>21 mmHg at the screening or randomization visits, or being treated for glaucoma in either eye. * Diagnosis of: ongoing ocular infection; severe/serious ocular condition that in judgment of Investigator could confound study assessments or limit compliance; or have been exposed to an investigational drug within 30 days prior to screening. * In the opinion of the Investigator or study coordinator, be unwilling or unable to comply with study protocol or unable to successfully instill eye drops.