Imaging the Neurochemistry of Drug Addiction With PET (NCT02817698) | Clinical Trial Compass
CompletedEarly Phase 1
Imaging the Neurochemistry of Drug Addiction With PET
United States25 participantsStarted 2017-11-29
Plain-language summary
The investigators' project has two overarching goals. 1) The investigators will use newly developed positron emission tomography (PET) technology to investigate the dopaminergic neurochemistry of drugs of abuse including marijuana, traditional cigarettes, and cocaine, and 2) The investigators will extend PET technology to an additional neurotransmitter system - namely, the opioid-ergic system, using the same drugs of abuse.
Who can participate
Age range
18 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Men and women, aged 18-55 years
. Able to read and write English and give voluntary written informed consent
. Not treatment seeking or using treatment medications
. Have a Fagerström Test for Nicotine Dependence (FTND) rating of at least 3.
. Have been using at least 7 cigarettes per day for at least 1 year
. Carbon monoxide levels \> 10 ppm during intake evaluation
. Urine cotinine levels of \> 150 ng/mL during intake evaluation
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Dopamine Levels at Baseline and After Drug of Dependence Administration as Confirmed by PET Images.
Timeframe: 90 minute PET scan acquisition. Drug of dependence will be given at -35 mins
2
Change in Beta Endorphin Levels at Baseline and After Drug of Dependence Administration as Confirmed by PET Images.
Timeframe: 120 minute PET scan acquisition. Drug of dependence will be given at -35 mins