FMT for MDRO Colonization in Solid Organ Transplant

Inclusion Criteria * Age ≥18 years old * Solid organ transplant recipients: liver, intestinal, multivisceral transplants, heart, lung, pancreas or kidney transplant recipients * Transplant recipient at least \>30 days post solid organ-transplant * Transplant recipient must be available locally for follow up to 6-months post FMT transplant * Inpatient status at time of FMT * History of at least one or more treated infections in the last 90 days (bacteremia, UTI, pneumonia or abdominal collection with a positive culture with MDRO) due to an MDRO and the MDRO is likely of enteric origin (carbapenem resistant enterobacteriaceae (CRE), vancomycin resistant enterococci (VRE) or carbapenem resistant Pseudomonas (CRP). * Be without active infection for \>15 days: bacteremia, UTI, pneumonia or abdominal collection. * Be without a positive culture (except for stool) with MDRO (carbapenem resistant enterobacteriaceae (CRE), vancomycin resistant enterococci (VRE) or carbapenem resistant Pseudomonas (CRP) * Patients are not receiving antimicrobials (therapeutic or suppressive) within 48 hours of FMT * Solid organ prophylactic antimicrobials as per protocol will be held 24 hours before and 14 days post FMT e.g. trimethoprim/sulfamethoxazole 3x/week or dapsone 100 mg PO daily or weekly for PJP prophylaxis * Ganciclovir or valgancyclovir for CMV prophylaxis if required as per protocol can be continued. * Patients have a positive surveillance rectal culture for evidence of colonization. Exc…