Endobronchial Valves in Inoperable Patients With Haemoptysis

Inclusion Criteria: * ≥18 years of age * Written informed consent * Current or previously documented admission to hospital with large volume haemoptysis (\>200ml/24hour); or haemoptysis with haemodynamic compromise (SBP \< 100mmHg for 15 minutes) or requiring fluid resuscitation; haemoptysis requiring intubation or deemed life-threatening by attending clinicians. * The cause of haemoptysis must be due to severe underlying lung destruction/ bronchiectasis, post-tuberculous lung damage or the presence of an aspergillomata. * Primary bronchial artery embolisation not considered technically possible\* or failed (defined as ongoing haemoptysis of at least 100 ml per day for 7 days or more, cumulative blood loss of \> 200 ml / 24 hours, or any volume resulting in a systolic blood pressure \< 100 mmHg for 15 minutes or necessitating resuscitation with vasopressors during a period of 30 days after BAE) and repeat BAE not considered feasible\* * Lung resection not possible because of poor cardiopulmonary reserves (as defined by the current ERS/ESTS clinical guidelines28, independently reviewed by a team of consisting of a thoracic surgeon, pulmonologist and anaesthesiologist who will need to in absolute agreement on inoperability and/or lack of cardiopulmonary reserve) Exclusion Criteria: * Haemodynamic instability (defined as SBP\< 90mmHg requiring ongoing fluid resuscitation or inotropic support) * Patients necessitating mechanical ventilation because of respiratory failure or ai…