Intrapartum Effect of Vancomycin on Rectovaginal GBS Colonization

Vancomycin Arm Inclusion Criteria * Women aged 18 years or older * Pregnancies of at least 37w0d gestation at delivery * History of high-risk allergy to penicillin (including pruritic rash, urticaria, swelling, anaphylaxis) * Women who are GBS positive * Culture proven resistance or * Unknown resistance to clindamycin or erythromycin Exclusion Criteria * Women with low risk allergy to penicillin * History of allergy to vancomycin * History of Red Man Syndrome * History of renal or hepatic disease * Immunocompromised patients * History of chronic steroid use in current pregnancy * Patient with fever or signs of chorioamnionitis on admission Penicillin Arm Inclusion Criteria * Women aged 18 years or older * Women who are GBS positive * Pregnancies of at least 37w0d gestation at delivery Exclusion Criteria * Immunocompromised patients * History of chronic steroid use in current pregnancy * Patient with fever or signs of chorioamnionitis on admission