Active — Not RecruitingNot Applicable

Neural Circulatory Control and SUDEP Risk.

United States39 participantsStarted 2016-06

Plain-language summary

The investigators believe epilepsy alters the way the body controls blood pressure, heart rate and breathing, and these changes increase the risk of sudden unexpected death in patients with epilepsy (SUDEP). SUDEP-7 is a risk scoring tool which may correlate with these changes to the heart and blood vessels. This research study measures those differences which may help identify new markers to help predict those patients at greatest risk in the future.

Who can participate

Age range18 Years – 90 Years

SexALL

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Inclusion Criteria: * Adults aged 18-90 * Able to consent Exclusion Criteria: * History of non-epileptic spells/seizures, * Children/adolescents under age 18 years * Pregnancy * Non-compliance with Epilepsy Monitoring Unit safety procedures * Unable to consent * History of dysautonomia * Chronic Obstructive Pulmonary Disease (COPD) * Asthma (active requiring therapy) * Pulmonary hypertension * Known Structural Heart Disease * Heart failure * Myocardial infarction * Stroke * Seizures due to traumatic injury * Prior surgery for epilepsy * Vasculitis * Raynaud's * Smoking (current or within the last 6 months)

What they're measuring

Abnormal neural circulatory control in patients with epilepsy and high SUDEP-7 scores compared to patients with epilepsy and low SUDEP-7 scores.

Timeframe: 24 hours

Abnormal neural and respiratory control in the ictal and peri-ictal phase of patients with epilepsy and a high SUDEP-7 score when compared to patients with epilepsy and a low SUDEP-7 score.

Timeframe: 3-7 days

Trial details

NCT IDNCT02813980

SponsorMayo Clinic

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2030-12

View on ClinicalTrials.gov More Epilepsy trials