CompletedNot Applicable

Tolerance of Myocardium to Ischemia Injury

France88 participantsStarted 2016-01

Plain-language summary

This study aims to understand the impact of time-of-the day on human myocardial tolerance to ischemia-reperfusion by exploring atrial myocardium biopsied during cardiac surgery. Patients scheduled for non-urgent cardiac surgery (coronary artery by-pas graft and/or aortic valve replacement) will be assigned to a morning or an afternoon cardiac surgery based on randomization. Myocardial biopsies will be explored in ex vivo conditions mimicking ischemia-reperfusion.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient scheduled for coronary artery bypass graft surgery and/or aortic valve replacement with extra-corporeal circulation * Patient in sinus rhythm at the time of surgery * Patient older than 18 * Patient able to understand the information and consent forms Exclusion Criteria: * Medical history of type 2 diabetes, atrial fibrillation or use of class III anti-arhythmic drug * left ventricle ejection fraction \< 40% * Pregnancy * Patient in emergency condition

What they're measuring

ischemia reperfusion injury in ex vivo conditions

Timeframe: the day of the myocardial biopsy

Trial details

NCT IDNCT02812901

SponsorUniversity Hospital, Lille

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-07

View on ClinicalTrials.gov More Reperfusion Injury trials