Can Nephrocheck™ Predict the Reversibility of Early, Acute Kidney Injury During Septic Shock? (NCT02812784) | Clinical Trial Compass
CompletedNot Applicable
Can Nephrocheck™ Predict the Reversibility of Early, Acute Kidney Injury During Septic Shock?
France184 participantsStarted 2015-09-16
Plain-language summary
Patients with septic shock in the intensive care unit have an elevated risk of developing acute kidney injury (AKI).
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 or over
* Septic shock (according to Bone's criteria) within 4 hours of introduction of catecholamines
* AKI, characterized by a KDIGO score ≥ 1
* Social security coverage
Exclusion Criteria:
* AKI requiring emergency RRT (in the critical care physician's opinion).
* Anuria
* Stage 4-5 chronic kidney failure with a GFR below 30 ml/min.
* Rapidly progressing renal disorders (glomerulonephritis, HUS, blockage, etc.)
* Obstructive AKI
* Probable glomerular damage (nephritic syndrome, nephrotic syndrome, chronic glomerulonephritis)
* Pregnancy or breastfeeding
* Legal guardianship or lack of social security coverage.
* Cardiocirculatory arrest
* Life expectancy \<48 hours.
* Child C cirrhosis
* Prior occurrence of AKI during the current hospital stay
* Transplantation
* Subject participating in another study with an exclusion period ongoing at the time of the pre-inclusion
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial used something called the Nephrocheck™ test to try to predict whether early kidney injury during septic shock could reverse itself — has this test become part of standard monitoring practice for kidney injury in septic shock, and could it be relevant to my situation?
2Since the trial was measuring kidney injury using the KDIGO classification system, can you explain what KDIGO staging means for my kidneys specifically, and how it helps guide treatment decisions in my care?
3This study was completed — does that mean results are available, and if so, what did they show about whether Nephrocheck™ actually predicted recovery of kidney function in patients with septic shock?
4Given that this was a monitoring and prediction study rather than a treatment trial, are there any practical changes to how kidney injury is detected or managed early in septic shock that I should know about based on research like this?
5If Nephrocheck™ or similar biomarker tests aren't yet standard where I'm being treated, are there other tools or markers my care team is using to track whether my kidneys are recovering during a critical illness?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.