UnknownNot Applicable

Gonadal Hormone, Gonadotropin and Cardiovascular Events

China8,000 participantsStarted 2011-07

Plain-language summary

Deficiency in gonadal hormone has been considered to play a role in ageing related increased incidence of cardiovascular events. But the mechanism has not been fully elucidated. On the other hand, the dramatic increase in gonadotropin level didn't drew much attention when talking about the increased risk of cardiovascular disease during menopausal transition. This study aim to investigate the association between gonadal hormone, gonadotropin and long-term cardiovascular events.

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male or female with intact uterus and at least one ovary * Aged of 18 to 75 years old; Exclusion Criteria: * Pregnancy or lactation women; * Presence of pituitary/hypothalamic disorders, polycystic ovarian syndrome or other endocrinal and metabolic disorders that known to compromise hypothalamic-pituitary-gonadal function; * Receiving psychotropic or hormonal medications including hormonal contraception and hormone therapies; * Taking lipid-lowering agents or hypoglycemic agents and other drugs that known to influence cardiovascular health; * Obviously poor compliance.

What they're measuring

Rate of first cardiovascular disorder events

Timeframe: Measured after 10 years of follow-up

Cardiovascular disease mortality

Timeframe: Measured after 10 years of follow-up

All-cause mortality

Timeframe: Measured after 10 years of follow-up

Trial details

NCT IDNCT02810821

SponsorShandong Provincial Hospital

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2023-06

View on ClinicalTrials.gov More Aging trials