CompletedNot Applicable

Prevalence of Pancreatic Anomalies of Patients With a 1st Degree Familial History of Pancreatic Adenocarcinoma

France200 participantsStarted 2015-06

Plain-language summary

Pancreatic adenocarcinoma is the 4th leading cause of cancer in the USA. Its incidence is increasing both in France and in Europe, whereas all the other cancers are decreasing in Europe. Moreover, its seriousness is still high, with a mortality rate higher than the average incidence. The aim of PAPAFA study is to assess the prevalence of the pancreatic anomalies which can be revealed thanks to imaging, for patients having a 1st degree pancreatic adenocarcinoma familial history. This could allow detection of lesions which are less than 10 mm long, and improve the dark prognostic of this pathology.

Who can participate

Age range40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients with a 1st degree familial history of pancreas adenocarcinoma * patients older than 40 * patients whose life expectancy is \> 3 months * inform and consent form signed * patient insured under the French social security system Exclusion Criteria: * contraindication to the MRI (pace-maker, implanted metallic material, medical history of allergy to the contrast agent, end-stage renal failure, pregnancy, claustrophobia) * contraindication to anesthesia to do the echo endoscopy * 1st degree family history of 2 pancreas adenocarinomas * medical history of allergy to benzylic alcool * contraindication to dimeglumine gadobenate * pregnant or breastfeeding woman, according to the questioning * subjets who don't have the legal capacity to consent

What they're measuring

Number of patients for whom the MRI and/or the echo endoscopy has shown a parenchymatous or ductal pancreatic anomaly

Timeframe: six months after the last inclusion

Trial details

NCT IDNCT02810730

SponsorCentre Hospitalier Saint Joseph Saint Luc de Lyon

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-12