CompletedPhase 2

Pneumococci and Hib Vaccination After Neurotrauma or Neurosurgery

85 participantsStarted 2001-01

Plain-language summary

The purpose of this study is to determine wether skull trauma or neurosurgery affect the immune response to two vaccine types.

Who can participate

Age range17 Years

SexALL

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Inclusion Criteria: * Basilar skull fracture or transsphenoidal pituitary gland surgery * Own or presumed consent (by next of kin of unconscious) Exclusion criteria * None

What they're measuring

Change from baseline of IgG anti-Hib (ug/ml)

Timeframe: baseline and 3 weeks

Change from baseline of IgG anti-Hib (ug/ml)

Timeframe: baseline and 6 weeks

Change from baseline of specific IgG against pneumococcal serotypes 4, 6B, 9V, 14, 18C, 19F and 23F (ug/ml)

Timeframe: baseline and 3 weeks

Change from baseline of specific IgG against pneumococcal serotypes 4, 6B, 9V, 14, 18C, 19F and 23F (ug/ml)

Timeframe: baseline and 6 weeks

Trial details

NCT IDNCT02806284

SponsorUppsala University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2008-01

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