MASked-unconTrolled hypERtension Management Based on Office BP or on Out-of-office (Ambulatory) BP Measurement

Inclusion Criteria: * Male and female subjects * Age 35-80 years * Masked uncontrolled (in treatment) hypertension: office BP \<140/90 mmHg, and one or more of the following situations: * Ambulatory daytime BP \>135/85 mmHg * Ambulatory night-time ABP \> 120/70 mmHg * Ambulatory 24h ABP \>130/80 mmHg * eGFR ≥45 mL/min/1.73 m2 (CKD-EPI creatinine equation 2009) Exclusion Criteria: * eGFR \<45 mL/min/1.73 m2 (CKD-EPI creatinine equation 2009), and in particular severe chronic renal failure defined as serum creatinine \> 250 umol/l; * Patients in unstable clinical conditions; * Known secondary hypertension; * Orthostatic hypotension (SBP fall \> 20 mmHg on standing); * Dementia (clinical diagnosis); * Hepatic disease as determined by either AST or ALT values \> 2 times the upper limit of normal * History of gastrointestinal surgery or disorders which could interfere with drug absorption * Known allergy or contraindications to one of the drugs to be administered in the study * History of malignancy including leukaemia and lymphoma (but not basal cell skin cancer) within the last 5 years * History of clinically significant autoimmune disorders such as systemic lupus erythematosus. * History of drug or alcohol abuse within the last 5 years * History of non-compliance to medical regimens and/or patients who are considered potentially unreliable * Inability or unwillingness to give free informed consent * Pregnancy or planned pregnancy during study period.