Pathophysiology of Paget's Disease of Bone

Inclusion Criteria for Cases: * Men and women between the ages of 18-99 years who have evidence of active Paget's disease of bone as clinically and/or radiographically defined by: * Increased serum alkaline phosphatase or increased serum collagen type 1 c-telopeptide (CTX) or increase in urinary pyridinoline at diagnosis * AND history of at least one of the following signs/symptoms: Pagetoid lesions(s) on x-ray/CT/MRI, increased uptake of radioactive substance by bone scan, bone pain, fracture, hearing loss, headache, hypercalcemia, or bony deformity. Inclusion criteria for controls: * Men and women between the ages of 18-99 years who match age within 5 years of cases and gender who do NOT have evidence of Paget's disease of bone as defined by: * No bone pain or bony deformity * Normal serum alkaline phosphatase Exclusion Criteria: * Osteosarcoma or other blastic bony metastases alone * Fibrous dysplasia of bone * Hyperostosis frontalis interna * All men and women \< 18 years or \> 99 years * Pregnancy (women) determined by self-report * Current use of oral contraceptive tablets or Depo-Provera™ (women) * Current use of hormone replacement therapy * Creatinine clearance \< 60 ml/min./1.73 m2 by Cockcroft-Gault based on most recent serum creatinine level (if greater than 1 year since last assessment, will be measured on collected blood sample to verify eligibility) * Current smoking or tobacco use * Alcohol use greater than 3 units daily * Use of thiazolidinedio…