Clinical Study to Evaluate the STENTYS Xposition S for Treatment of Unprotected Left Main Coronary Artery Disease

Main Inclusion Criteria: * Subject ≥ 18 years old; * Presence of coronary artery stenosis in the unprotected Left Main (LM) Coronary Artery which is indicated for PCI and Xposition S stent treatment * Left Main Coronary Artery reference vessel diameter ranging from 2.5 mm to 6.0 mm; * The subject is able to provide voluntary informed consent, willing to comply with all study requirements and sign the written informed consent. Main Exclusion Criteria: * Recent STEMI (\<1 month) ; * SYNTAX score ≥ 33 ; * Highly calcified lesions or excessive tortuosity at target lesion site; * Subject unable to comply with dual antiplatelet therapy as recommended per guidelines; * Planned cardiac surgery or valve intervention within the next 12 months. * Participation to other investigational drug or device studies that have not reached their primary endpoint.