TACE vs TACE+SBRT for Unresectable Hepatocellular Cancer

Inclusion Criteria: * Diagnosis of HCC. Tissue diagnosis is not mandatory however desirable. In the absence of tissue diagnosis imaging findings characteristic of HCC will be used. i.e. in high risk population a nodule with arterial phase enhancement and wash out during portovenous phase will be considered as diagnostic of HCC. In patients where one imaging is not conclusive another imaging modality will be used. However if second imaging is also inconclusive and Alpha Feto Protein (AFP) is within the nondiagnostic or borderline range than tissue diagnosis will be deemed mandatory. * Barcelona Stage B/ Barcelona A not deemed suitable for Sx or refuse surgery. Child Pugh A/Select Child Pugh B (score7/10). * Eastern Cooperative Oncology Group Performance Status 0-1. * Total number of measurable target lesions 2 or less than 2, can be encompassed within a single hepatic field or 2 different hepatic fields without exceeding safe dose limit constraints. * Optimal predicted liver volume reserve \>700 cc. No Contraindication for TACE. Tumor considered to be sufficiently away from GI structures to deliver safe radiation dose (\>1 cm). * Willing for molecular banking of tumour tissue (optional). Exclusion Criteria: * Metastatic or nodal disease on staging investigations. * Child C Cirrhosis or previous history of liver failure. Expected life span \<6 months. * Active variceal bleeding or other signs of hepatic decompensation. * Portal venous thrombosis rendering patients unsuitable…