Oxidative Stress on Muscle Dysfunction in Hemodialysis Patient

Inclusion Criteria: * Age between 40-80 years old * less than 150min by week of moderate to vigorous physical activity * Chronic renal failure (glomerular filtration rate less than 15mL by min) requiring hemodialysis * Patient placed on the kidney transplant waiting list of MontpellierCHU * No indication against temporary kidney transplant * Review cardiovascular older than two years * Patient not under guardianship or trusteeship * Clinically stable state Absence or recent infection within 3 months prior to inclusion Absence of progressive neoplasia No recent acute decompensation of chronic disease (thrust of heart failure, respiratory decompensated cirrhosis). Absence of recent stroke * musculoskeletal and neurological states of the lower limbs which allow the realization of the proposed functional tests. * Patient has given written informed consent * Absence of congenital or genetic degenerative muscle disease Exclusion Criteria: * Terminal chronic renal failure without replacement therapy * Local anesthesic hypersensibility * Corticosteroid treatment upper than 3 month * COPD * Oral anticoagulants * Previous renal transplantation * Subject not affiliated with a social security scheme, beneficiary or not such a plan * Major subject protected by law or unable to consent under Article L 1121-8 of the Public Health Code * Vulnerable person under Article L.1121-6 of the Public Health Code