CompletedNot Applicable

Follicle Activation by Inhibition of the Hippo Pathway

Denmark20 participantsStarted 2016-04

Plain-language summary

The aim of this project is to activate recruitment and growth of resting primordial follicles in the ovaries of women with diminished ovarian reserve, in attempt to increase the chance to become pregnant, either naturally or after assisted reproduction.

Who can participate

Age range25 Years – 39 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Infertility with indication for IVF/ICSI * Imminent POI, still cycling * Age 25 - 39 years * Two ovaries * Serum AMH measurements \< 5 pmol/l (two independent measurements) * Antral follicle count (AFC) (sum of both ovaries \< 5) Exclusion Criteria: * Ovarian pathology (endometriosis, cysts) * Known chromosomal abnormality * Known autoimmune disease (except TPO-antibodies) * Patients who have contraindication for laparoscopy

What they're measuring

Number of follicles > 12 mm

Timeframe: Up to 6 month after the auto-transplantation

Trial details

NCT IDNCT02792569

SponsorAnders Nyboe Andersen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-12

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