Multimodal Imaging for Surveillance in Patients With Oral Potentially Malignant Disorders

Inclusion Criteria: * Subjects who are willing to participate. * Adult subjects with: a. clinically evident oral premalignant lesion (OPL) or suspicious oral mucosal lesion. or b. pathologic diagnosis of dysplasia or c. history of resected oral cancer or d. oral potentially malignant disorder (OPMD) or e. history of tobacco and/or alcohol exposure. * Ability to understand and willingness to sign a written informed consent document (ICD). Exclusion Criteria: * Known allergy to proflavine or acriflavine. * Pregnant females.