Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fi… (NCT02789098) | Clinical Trial Compass
TerminatedNot Applicable
Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fibrosis Using Positron Emission Tomography in Patients With ST-elevation Myocardial Infarction
Stopped: lack of patient
France30 participantsStarted 2016-10-13
Plain-language summary
Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure. Hemodynamic, metabolic and inflammatory mechanisms are involved in this pathophysiological process. Recent data demonstrated that remote, noninfarct-related region of the myocardium is also implicated. There is no data about the assessment of coronary endothelial function or myocardial fibrosis in the remote zone in patients with STEMI . The correlation between these parameters and left ventricular remodeling is not known.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* First ST Elevation Myocardial Infarction
* Primary Percutaneous Coronary Intervention (TIMI 3)
* Single vessel coronary artery disease
* Age over 18 years
* Informed Consent dated and signed
* Written and spoken French
* Beneficiary of social security insurance
Exclusion Criteria:
* No Primary Percutaneous Coronary Intervention
* TIMI 0-2 after Primary Percutaneous Coronary Intervention
* Significant two or three-vessel coronary artery disease (\> 70% stenosis in at least one of the other two coronary arteries)
* Past history of myocardial infarction before STEMI
* Mechanical complication (ischaemic mitral regurgitation, interventricular septal defect, cardiac tamponade) or clinical signs of heart failure
* Pregnant and / or lactating
* Age under 18 years or guardianship
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial was terminated before completing — does that mean the data collected so far is reliable enough to inform my care, or should I be cautious about any findings from it?
2The study was measuring coronary endothelial function and myocardial fibrosis using PET imaging after a heart attack — are these the same types of assessments that would be part of my standard follow-up care, or would participating in this kind of research involve extra procedures?
3Since this trial was terminated and is listed as 'not applicable' for phase, does that mean there's no approved treatment or intervention being tested here, and if so, how would joining an observational study like this actually benefit my recovery?
4Given that I've had an ST-elevation heart attack, are there other active trials or standard treatment pathways you'd recommend over a terminated observational study like this one?
5Could the PET imaging used in this study to measure heart scarring and blood vessel function give us useful information about my specific condition, and is that kind of imaging something you'd consider ordering for me outside of a research setting?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.