WithdrawnPhase 4

Effect of N-Acetylcysteine on Autologous Fat Graft Survival

Stopped: unable to hire research staff

0Started 2016-08-15

Plain-language summary

A single-centre triple-blind study looking at the addition of NAC to tumescent solution for liposuction and fat grafting in healthy patient volunteers already undergoing bilateral breast reduction. Three-dimensional reconstructions and volumetric analysis will be performed based on CT scans at 0, 1 and 3 months and then histological analysis will be performed after fat graft explantation at 3 months to determine fat graft vascularity and quality.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Women
✓. Desire and surgical indication for liposuction of the thigh/hip region for women already undergoing elective breast reduction surgery
✓. Age 18-45 years
✓. BMI of 20-30
✓. ASA Class I

Exclusion criteria

✕. Known chronic illnesses: Diabetes, HIV, renal/liver failure, metabolic disease, history of cancer or family pre-disposition of cancer, peripheral vascular disease, illness that would preclude a general anaesthetic
✕. Pregnancy or planned pregnancy within 1 year
✕. Contraindications to CT
✕. Previous hip/thigh surgery or injury
✕. Previous lower leg surgery/injury
✕. Smoker
✕. Breastfeeding
✕. Other disease according to investigator's judgment

What they're measuring

Change in fat graft volume over time

Timeframe: 0, 1 and 3 months

Trial details

NCT IDNCT02788292

SponsorNova Scotia Health Authority

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-11-16

View on ClinicalTrials.gov More Adipose Tissue Atrophy trials