CompletedNot Applicable

Vancomycin Plus Moxifloxacin Versus Vancomycin Plus Ceftazidime for the Treatment of Peritoneal Dialysis (PD)-Related Peritonitis

80 participantsStarted 2012-11

Plain-language summary

Intra-peritoneal administration of antibiotics covering both gram-positive and gram-negative organisms was recommended as first-line regimen for the management of peritoneal dialysis related peritonitis. Oral administration of quinolones can also achieve effective serum concentrations, and is more convenient and economical. We conducted a pilot randomized controlled study to compare the effects on peritonitis cure and relapsing rates between oral moxifloxacin plus IP vancomycin and conventional IP vancomycin plus ceftazidime.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * incident or prevalent peritoneal dialysis patients * diagnosis of acute peritonitis according to ISPD guideline * age \>18 years Exclusion Criteria: * receiving antibiotic treatment for other reasons when peritonitis occurred * contraindication to cephalosporin, vancomycin, or fluoroquinolones * concomitant exit-site or tunnel infection * requirement for immediate transfer to hemodialysis due to sepsis, gastrointestinal perforation or visceral inflammation, severe bowel obstruction, or ultrafiltration failure at the initiation of peritonitis * inability to tolerate oral administration due to severe gastrointestinal complication or other reasons * history of psychological illness or condition which interfered with ability to understand or comply with the requirements of the study * pregnant or breast-feeding

What they're measuring

Complete Cure Rate

Timeframe: within 4 weeks of completion of therapy

Trial details

NCT IDNCT02787057

SponsorPeking University First Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-04

Results submitted2020-03-11

View on ClinicalTrials.gov More Peritoneal Dialysis Associated Peritonitis trials