Curcumin in Preventing Gastric Cancer in Patients With Chronic Atrophic Gastritis or Gastric Intestinal Metaplasia

Inclusion Criteria: * PRE-REGISTRATION INCLUSION CRITERIA * Ability to understand and the willingness to sign a written informed consent document * Willingness to undergo screening tests and procedures * Willingness to provide blood and tissue samples for safety/toxicity monitoring and biomarker analyses * Willingness to avoid the use of curcumin or any over-the-counter or prescription medications containing curcumin or curcuminoids * REGISTRATION/RANDOMIZATION INCLUSION CRITERIA * Histologically-confirmed chronic multifocal atrophic gastritis (MAG) and/or gastric intestinal metaplasia (GIM) * Helicobacter pylori negative, defined as negative stool antigen testing and negative histological examination * Eastern Cooperative Oncology Group (ECOG) performance status =\< 1 * Aspartate transaminase (AST), alanine transferase (ALT) within institutional limits of normal or judged to be not clinically significant by the investigator * Alkaline phosphatase within institutional limits of normal or judged to be not clinically significant by the investigator * Platelets within institutional limits of normal or judged to be not clinically significant by the investigator * Hemoglobin within institutional limits of normal or judged to be not clinically significant by the investigator * White blood cells (WBC) within institutional limits of normal or judged to be not clinically significant by the investigator * Blood urea nitrogen (BUN) within institutional limits of normal or judged to be …