UnknownPhase 4

The Role of Ketamine in Preventing Cognitive Dysfunctions in Postoperative Period of Cardiac Surgery

Brazil50 participantsStarted 2016-04

Plain-language summary

The purpose of this study is to analyze the Ketamine with its anti-inflammatory profile would be able to prevent cognitive disorders in the postoperative period of cardiac surgery, since these disorders contribute to an impact on morbidity / mortality in this population.

Who can participate

Age range50 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients aged over 50 years. * Be submitted to cardiac surgery by sternotomy and with the use of cardiopulmonary bypass (CPB). * American Society of Anesthesiologists classification 1, 2,3 and 4. Exclusion Criteria: * Patients undergoing reoperation. * Patients undergoing heart transplantation. * Patients using vasopressor agents and / or ionotropic continuous preoperatively. * Patients with prior endotracheal intubation and consequently Ventilatory Assistance Mechanics. * Patients with documented psychiatric disorders. * Patients with previous cognitive disorders. * Patients with a history of alcohol or drug abuse. * Patients with a history of cerebrovascular accident (CVA) with less than 3 months.

What they're measuring

Change in cognitive disorder, defined by a drop of 2 points in the Mini-Mental State Examination

Timeframe: Baseline and 7 days

Detectable levels of inflammatory biomarkers in bloodstream, such as: P-selectin (CD62p- ng/ml), CD40L soluble (ng/ml), s100B (ng/ml)

Timeframe: Change from baseline at 6 hours and 24 hours after surgery

Trial details

NCT IDNCT02782429

SponsorFlavia orange

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-05

Contact for this trial

Rebeca GA Andrade, master

+55 81 988043844 bekinhagonelli@hotmail.com

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