SOFEED: Six Food vs. One Food Eosinophilic Esophagitis Diet Study

Inclusion Criteria: * Have diagnosis of EoE (based on consensus criteria) * Have histologically confirmed active disease \>15 eosinophils/hpf in either distal or proximal esophagus within 12 weeks of screening visit * Symptomatic (have experienced symptoms within the last month prior to enrollment) * Proton pump inhibitor (PPI) confirmation * Have a negative urine pregnancy test at screening if of childbearing potential Exclusion Criteria: * Have been treated with topical swallowed steroids within the last 2 months or systemic steroids within the last 3 months * Have pathological eosinophilia in segments of the GI tract other than the esophagus determined by local review * Have been diagnosed with a GI malabsorption disorder (i.e., Inflammatory bowel disease, Crohn's disease) or Celiac disease * Are currently on dietary therapy strictly avoiding milk or on a 6FED * Have concurrent H pylori gastritis or parasitic infection * Have history of anaphylaxis to milk (with current avoidance of milk) * Have previously failed strict dietary therapy clearly documented with one of these regimens or topical steroid treatment (i.e. have achieved histological remission of \<15 eos/hpf after having been on fluticasone or \>1mg budesonide per day). * Use of investigational drugs within 4 weeks (one month) prior to enrollment * Are concurrently receiving any of the prohibited medications for the study * On immunotherapy for pollen (if not on maintenance therapy) or immunoglobulin-E (IgE) -m…