WithdrawnNot Applicable

Severe CAV MRI in Heart Transplant Recipient

Stopped: PI left University

United States0Started 2012-05

Plain-language summary

Hypothesis: CAV is associated with fibrotic changes on cardiac MRI, altered levels of pathogenetically-related biomarkers, and specific RNA expression changes in the blood

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years * Provide informed consent * Successful orthotopic heart transplant within 15 years of enrollment Exclusion Criteria: * Chronic kidney disease with creatinine \>2.5 mg/dl * Ejection fraction \<45% if CAV or \<50% if no CAV * IV contrast allergy or reaction (gadolinium) * Active infection (febrile illness, cytomegalovirus or other significant infection) * Treated humoral rejection or cellular rejection grade 3A/2R or greater within 3 months * Contraindication to MRI

What they're measuring

Changes from baseline associated with severe CAV

Timeframe: 1 year

Trial details

NCT IDNCT02777255

SponsorUniversity of Minnesota

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2014-05

View on ClinicalTrials.gov More Cardiac Allograft Vasculopathy trials