The Entorhinal Cortex and Aerobic Exercise in Aging

Inclusion Criteria: * Age between 60-80 years * Physical inactivity/sedentary status (The American College of Sports Medicine defines a sedentary lifestyle as a lifestyle in which a person is not participating in at least 30 minutes of moderate intensity physical activity on at least three days per week for at least three months.) * Generally healthy * Living in the greater Boston area * Fluent in English (must have attended elementary school and higher in English) * Non-smoking Exclusion Criteria: * Poor vision that cannot be corrected with glasses or contact lenses * Presence of an acute infection * Diagnosis of kidney failure * Diagnosis of liver disease * Diagnosis of thyrotoxicosis/hyperthyroidism * Diagnosis of cancer * Diagnosis of severe anemia * Past or present conditions that affect cognitive functioning: * learning disability * neurological disorders or conditions (movement disorder, history of head trauma or stroke, epilepsy, etc.) * psychiatric disorders or conditions within last 5 years (depression, anxiety disorder, etc.) * Severe stress * Evidence of cognitive impairment (e.g. dementia) * Claustrophobia (fear of small, enclosed spaces) * Obesity * Past or present conditions that are counter indicators for participation in cardio-respiratory fitness assessment and physical exercise: * heart conditions (e.g. heart attack, arrhythmias, etc.) * circulatory conditions (e.g. uncontrolled hypertension, leg claudication, high cholesterol, etc.) * re…