The natural history and response to therapy of chronic hepatitis B infection in West Africa are currently poorly understood. In this study, employees of the Cameroon Baptist Convention Health Board (CBCHB) and spouses who are found to be hepatitis B positive on screening will be offered enrollment. Disease monitoring and treatment will be provided following current WHO guidelines. Clinical data will be prospectively recorded for 5 years, and bio-specimens will be frozen for future analysis.
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Proportion of subjects in each phase of chronic hepatitis B infection at enrollment
Timeframe: Enrollment
yearly incidence of compensated and decompensated cirrhosis in the study cohort
Timeframe: 5 years
yearly incidence of hepatocellular carcinoma in the study cohort
Timeframe: 5 years
Percentage of treated subjects who achieve and maintain a complete response to antiviral treatment.
Timeframe: 5 years